|
KMID : 0361020020450010056
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
2002 Volume.45 No. 1 p.56 ~ p.61
|
|
|
Effects of the Genetic Polymorphisms of CYP1A1 and GSTP1 on the Risk of Laryngeal Cancer in Koreans
|
|
이국행/Lee GH
심윤상/이용식/이병철/성명식/홍영준/김현주/김헌/김용정/Shim YS/Lee YS/Lee BC/Seong MS/Hong YJ/Kim HJ/Kim H/Kim YJ
|
|
|
Abstract
|
|
|
Background and Objectives: Smoking has been reported as an important risk factor of laryngeal cancer. Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase P1 (GSTP1) are genes that encode enzymes which are involved in the metavolism of carcinogens in cigarette smoke. In this study, we statistically tested the significances of smoking and genotypes of CYP1A1 and GSTP1 as risk factors of laryngeal cancer.
Materials and Method: In this case-control study, 84 pathologically proven laryngeal cancer patients and 168 age-and sex-matched controls were included as the study subjects. Information on smoking habit was collected using a self-administered questionnaire, and CYP1A1 and GSTP1 genotypes were analyzed using PCR-RFLP method. Chi-square test, Student’s t-test and conditional logistic analysis were used to test statistical significance.
Results: Smoking was turned out to be a significant risk factor of laryngeal cancer both in univariate and multivariate analyses. The CYP1A1 Ile/Ile genotype was significant in the univariate test, but the statistical significance disappeared in the multivariate conditional logistic model including smoking. The odds ratio (95% confidence interval) of GSTP1 A/A genotype for laryngeal cancer was 0.71 (0.38, 1.33), which was not statistically significant.
Conclusion: Smoking is the most potent risk factor among the three factors, and the genotypes of CYP1A1 and GSTP1 would not be major risk factors for laryngeal cancer in Koreans.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|